Dynamic representation of appetitive and aversive stimuli in nucleus accumbens shell D1- and D2-medium spiny neurons
Ana Verónica Domingues, Tawan T. A. Carvalho, Barbara Coimbra, Gabriela J. Martins, Raquel Correia, Ricardo Gonçaslves, Marcelina Wezik, Rita Gaspar, Luísa Pinto, Nuno Sousa, Rui M Costa, Carina Soares-Cunha, Ana João Rodrigues · FENS Forum 2024
The nucleus accumbens (NAc) is a key brain region involved in rewarding and aversive responses. The NAc is mainly composed of GABAergic medium spiny neurons (MSNs) expressing either dopamine receptor D1 or D2. Some studies propose an antagonist role of D1- and D2-MSNs, whereas others suggest that both populations play distinct, but not necessarily opposing roles in valence behaviour.Here, we used deep brain 1-photon calcium imaging to follow NAc D1- or D2-MSN activity in response to opposing valence stimuli and during associative learning. In addition, we used optogenetics to further unravel t
ePoster · Neuroscience