An in silico population of compartmental models of neurons from primary hippocampal cultures
Matus Tomko, Martin Mittag, Lucia Dubiel, Alžbeta Idunková, Katarína Ondáčová, Stanislava Bukatová, Michal Dubovický, Peter Jedlicka, Ľubica Lacinová · FENS Forum 2024
Computational models play a key role in elucidating the complex behaviour of neurons. However, many of these models are tuned to the electrophysiological features of adult neurons, leaving a significant gap in the modelling of immature perinatal neurons. This study aims to bridge this gap by generating a population of computational models representing hippocampal neurons from primary hippocampal cultures of neonatal rat brains and comparing them with models of adult neurons in terms of variability in ion channels and electrophysiological behaviour. Using the TREES toolbox, we reconstructed the
ePoster · Neuroscience