Amyotrophic lateral sclerosis and the central nervous system: The effect of the disease on cortical electrophysiological activity
Ilaria Donati della Lunga, Martina Brofiga, Valerio Barabino, Francesca Bacchetti, Bruno Burlando, Marco Milanese, Paolo Massobrio · FENS Forum 2024
Amyotrophic Lateral Sclerosis (ALS) is a progressive neurological disorder characterized by the gradual degeneration of cells in the spinal cord, brainstem, and motor cortex, leading to manifestations such as weakness, muscle atrophy, and spasticity (Elisen, 2009). A comprehensive understanding of the disease process is currently lacking, making preclinical ALS models crucial to study the mechanisms of pathology insurgence, characterize the disease and test therapeutics approaches. Pathological in vitro models emerged as viable alternative to in vivo studies, consolidating a non-invasive appro
ePoster · Neuroscience