Transcriptomic and sublaminar dynamics of the developing human frontal cortex: A novel approach
Janja Kopić, Parthiv Haldipur, Leonarda Grandverger, Jure Krasić, Zeljka Krsnik · FENS Forum 2024
Our recent study showed specific molecular and cellular differences in sublaminar dynamics of the dorsal/dorsolateral and orbitobasal part of the prospective human frontal cortex (Kopić et al, 2023). More particularly, during early midfetal development, dorsal part of the prospective frontal cortex showed waves of migratory cells, representing future deep projection neurons (DPN) characterized by diverse molecular markers, while orbitofrontal cortex displays "double" cortical plate pattern shown by DPN markers (TBR1, TLE4, SOX5). Cell-sparse layer in between these “two plates” shows DCX+ cells
ePoster · Neuroscience