Topic: degradative autophagy

Glioblastoma is an aggressive primary brain cancer with poor prognosis and limited therapeutic options. In tumors, glioblastoma cells control their microenvironment through the secretion of proteins and other factors. Work from our lab has identified a new unconventional secretion mechanism that is dependent on VAMP7, a tetanus neurotoxin insensitive v-SNARE. We have shown that Endoplasmic Reticulum (ER) and mitochondrial fragments can be incorporated into late endosomes and can later be released by an unconventional secretory mechanism. This process is more efficient in the absence of degrada