Implication of polyunsaturated fatty acid (PUFA) biostatus in dopamine transmission-related reward processing deficits
Lola Hardt, Maria Moreno-Montano, Andrea Contini, Anna Petitbon, Maria-Florencia Angeloa, Roman Walle, Julien Catanese, Nina Fayad, Florian Hontarrede, Jean-Christophe Helbling, Fabien Ducrocq, Emmanuel Valjent, Pierre Trifilieff · FENS Forum 2024
Deficits in reward processing are a characteristic symptomatic dimension of psychiatric diseases such as major depression, bipolar disorder and schizophrenia. These deficits have been linked to the dysfunction of the mesocorticolimbic dopamine transmission suggesting the existence of common underlying pathophysiological mechanisms. Numerous clinical studies have described a decrease in n-3 polyunsaturated fatty acids (PUFAs) in subpopulations of patients suffering from psychiatric disorders (Conklin et al., 2010; Messamore and McNamara, 2016). Moreover, preclinical results from our laboratory
ePoster · Neuroscience