Engaging the delayed non-match to position task in rats as a test of inflammatory-induced cognitive impairment and model to assess pro-cognitive anti-inflammatory agents
Matthew McAuslan, Danka Kozareva, Fionn Dunphy-Doherty, Myles Corrigan, Jack Prenderville, Andrew Harkin · FENS Forum 2024
The delayed non-match to position task (DNMTP) is a translational instrumental learning paradigm commonly applied preclinically to assess higher executive functions including attention and working memory in rats. In this study, the effects of acute inflammatory challenges were assessed on cognitive performance in the DNMTP task.. Male and female Wistar rats were trained to criteria on the task. Initially, in validating the test, the effect of treatment with the muscarinic receptor antagonist scopolamine (0.02mg/kg, s.c.), known to disrupt performance in the task, was confirmed. Sex differences
ePoster · Neuroscience