Determination of the threshold plasma Aβ42/40 ratio for Alzheimer's disease diagnosis and identification of confounding factors: The role of CNS-derived EVs
Emilien Boyer, Lise Colmant, Louise Deltenre, Marion Dourte, Esther Paître, Bernard Hanseeuw, Pascal Kienlen Campard · FENS Forum 2024
Hallmark proteins implicated in Alzheimer's disease (AD), amyloid and tau, can now be quantified in plasma samples using single-molecule array (SIMOA). However, these proteins not only circulate in plasma but are also present in neurally-derived extracellular vesicles (NDEVs) secreted by neurons into the plasma. Our objective is to identify the most promising candidate for plasma AD diagnosis and assess the impact of NDEVs on such quantifications.Plasma samples were collected from clinically normal (CN) participants (N=236, female/male sex ratio=1.95, mean age 66.4±7.6, Apoε4 positive n=68, Ap
ePoster · Neuroscience