Topic: delirium-like behavior

Cognitive impairment is a risk factor for falls, particularly true in the elderly due to age-related decline. Chronic drug consumption, often encountered in elder, has been reported to increase this risk, although underlying mechanisms remain to be uncovered (cumulative effect due to chronic use or increased half-life/higher sensitivity). Among opioid drugs mostly prescribed in elderly within European countries, tramadol is associated to risk of falls. Herein, we investigated the different types of cognitive processes affected after acute or chronic tramadol administration. We conducted a 6-we