Application of single-cell CRISPRi/a screen to characterize multiple sclerosis-associated single nucleotide polymorphisms in oligodendrocytes
Karl Carlström, Eneritz Agirre, Ting Sun, Noah Holzleitner, Gonçalo Castelo-Branco · FENS Forum 2024
Multiple sclerosis (MS) is a prevalent demyelinating disease that primarily affects young adults. Within the realm of MS patients, the extent of disease severity and progression differs greatly across individuals. Studies conducted on post-mortem tissue samples have characterized complex lesion types that diverge significantly on the composition of oligodendrocyte (OLG) lineage cells and their degrees of remyelination, both across different individuals and within each MS patient1. To date, the intrinsic genetic factors that potentially impact OLG-mediated de- and re-myelination in MS lesions,
ePoster · Neuroscience