Topic: dendritic protein synthesis

One crucial component for synaptic functionality is the proteome within the spines, which is fueled by local mRNA translation and the influx of proteins from the dendrite. A neuron could recruit proteins from the dendritic pool or increase local synthesis to increase the protein number at the synapses. However, since only about 10-20% of proteins have local mRNAs in the dendrites, the question arises; how do the other 80-90% of dendritic and synaptic proteins dynamically control their copy numbers without having the ability to increase the synthesis rate of the protein of interest locally. We