An activity-dependent local transport regulation via local synthesis of kinesin superfamily proteins (KIFs) underlying cognitive flexibility
Suguru Iwata, Momo Morikawa, Tetsuya Sasaki, Yosuke Takei · FENS Forum 2024
Multiple neuronal functions require decentralized processes including activity-dependent localized protein synthesis. However, how local protein synthesis drives the dendritic remodeling is still elusive. Kinesin superfamily proteins (KIFs) are microtubule-based motor proteins that transport various types of cargos to a specific area where they function. This intracellular transport system is essential for neuronal morphogenesis, function, and survival. KIF17 and KIF5A are abundantly expressed in neurons and have been suggested to transport NMDAR and AMPAR in neuronal dendrites, respectively.
ePoster · Neuroscience