Topic: dendritic spine turnover

The computational study of neural circuits canonically assumes that the underlying connectivity of the network is static in the absence of learning. However, it has long been understood that endocrine factors can influence network connectivity in a cyclical manner, as demonstrated by a reliable 30% fluctuation in synaptic density observed across the estrous cycle in vitro. Despite this, the mechanisms underlying endocrine modulation of the hippocampal network remain poorly understood. Here, we used chronic two-photon (2P) imaging to demonstrate that both dendritic spine turnover and place cell