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ISMB/ECCB 2027
The 35th ISMB conference joined with the 26th annual ECCB, hosted by the International Society for Computational Biology at the Bella Center Copenhagen and virtually - the year's most important computational biology event.
Experimental research in patients with migraine
AI for routine EEG and beyond
Deciphering the pathogenesis of migraine with human models
New Frontiers in Understanding and Treating Migraine Headaches
In this presentation I will describe how the CGRP project started and culminated in the development of gepants and mAbs for successful therapy. The outstanding question regarding the preponderance of female migraineurs also remains. I will present views on the reason behind this and suggest that understanding the hormonal influence will pave the way to alleviating hormone related migraine.
40 years of headache research
Lifelong devotion to headache research has led to many discoveries. First a series of studies of brain blood flow during attacks of migraine. The results showed changes compatible with cortical spreading depression in migraine without aura effectively negating the then prevailing vasospastic/ischemic theory. In migraine without aura no changes in brain blood flow. This difference was crucial for the separation of migraine with aura and migraine without aura in the first and subsequent editions of the international headache classification headed by me. Then a human migraine provocation model that has elucidated the molecular mechanisms of migraine. Successively we showed in series of papers the importance of nitric oxide, histamine, CGRP, PACAP and prostanoids. Therapeutic effectiveness of antagonizing these provokers by tonabersat, L-NMMA, CGRP receptor antagonists and monoclonal antibodies and of NSAIDs. Present and future attempts to put all these signaling mechanisms into a framework but it is not easy