Distinct neuropeptide secretion mechanisms across cell types in the mammalian CNS
Fiona H. Murphy, Adlin Abramian, Urszula Bagińska, Enedina Zepcan, Noortje van Geest, Ruud F. G. Toonen, Matthijs Verhage · FENS Forum 2024
The release of neuropeptides from dense-core vesicles (DCVs) is crucial in the nervous system. We previously identified RAB3 as a specific regulator of neuropeptide secretion in hippocampal neurons, as the ablation of all four RAB3 paralogs leads to a total block of DCV exocytosis. However, it is unknown whether this phenotype is conserved across different neuronal cell types. Here, we investigate potentially divergent regulatory mechanisms of RAB proteins governing DCV exocytosis in distinct neuronal populations. Our study identifies RAB3A as the key regulator of DCV exocytosis in hypothalami
ePoster · Neuroscience