Topic: depolarisation block

Slow brain rhythms, observed during slow-wave sleep or seizures, often coincide with oscillations in extracellular potassium levels. These rhythms have a lower frequency compared to a typical neuron’s tonic firing. Mechanisms organizing these rhythms are believed to rely on synaptic interactions within the network or intrinsic cellular voltage dynamics, likely a combination of both. This study focuses on single neurons that can produce slow rhythms, which in turn can organize slow rhythms in neural networks. Common theories attribute intrinsic slow bursting of neurons to ion channels with slow