Crosstalk between AQP4-dependent increase of extracellular adenosine and dopamine neurotransmission during cocaine-induced psychiatric behaviors
Mitsuhiro Morita, Rina Yamane, Satoshi Okada · FENS Forum 2024
Our previous studies have shown that the water influx via astrocytic AQP4 induces the release of ATP and subsequent increase of extracellular adenosine. Since antagonistic interactions between adenosine and dopamine have been shown by biochemical and pharmacological studies, the present study investigated the possibility that the AQP4-dependent adenosine increase interacts with dopamine neurotransmission, focusing on the effects of cocaine. The stimulus effect of acute cocaine treatment was abolished in AQP4 ko mice, while mice treated with caffeine for one week showed the increase of the stim
ePoster · Neuroscience