Topic: Despair-like behaviour

The increasing prevalence of psychiatric disorders, such as depression, highlights the need to elucidate their underlying neurobiological mechanisms. The lateral habenula (LHb) and its neuronal activity contribute to the pathophysiology of depression when dysfunctional. Among the existing rodent models of depression, chronic corticosterone administration for 3-4 weeks recapitulates relevant behavioural aspects of the disease such as anhedonia and increased passive coping. However, the temporal emergence of these features and the cellular underpinnings remain unclear. Thus, we assessed the emer