Adolescent oligodendrogenesis and myelination restrict neuronal plasticity in the mammalian cortex
Wendy Xin, Megumi Kaneko, Richard Roth, Albert Zhang, Sonia Nocera, Jun Ding, Michael Stryker, Jonah Chan · FENS Forum 2024
Developmental myelination is a protracted process in the mammalian brain. One theory for why oligodendrocytes mature so slowly posits that myelination may stabilize neuronal circuits and temper neuronal plasticity as animals age. We tested this theory in the visual cortex, which has a well-defined critical period for experience-dependent neuronal plasticity. During adolescence, visual experience modulated oligodendrocyte maturation in visual cortex. To determine whether oligodendrocyte maturation in turn regulates neuronal plasticity, we genetically blocked oligodendrocyte differentiation and
ePoster · Neuroscience