Fasting exposure during early pregnancy elicits schizophrenia-like behavioral changes in male offspring associated with impaired synaptic spine density
Hongbo Wang, Motoko Maekawa, Mai Sakai, Zhiqian Yu, Hiroaki Tomita, Yuji Owada · FENS Forum 2024
Numerous cohort studies on the “Dutch famine,” in which pregnant women were exposed to a severe food shortage, have indicated a linkage between famine exposure during early pregnancy and a heightened risk of schizophrenia (SCZ) onset among offspring. These findings endorsed the Developmental Origins of Health and Disease (DOHaD) theory. However, the underlying mechanisms remain unclear. In this study, we exposed fertilized mice to a 16-hour overnight fast on embryonic day 1 (E1), E3, and E5, to mimic early pregnancy famine exposure. Offspring were examined for phenotypes in adulthood. Using 10
ePoster · Neuroscience