Topic: Developmental psychiatric disorders

Developmental psychiatric disorders, including schizophrenia, autism, and ADHD, impose significant socio-economic burdens and reduce patients’ life expectancy by 10-20 years due to their early onset and chronic impact. While the genetic implication is evident, pinpointing the implicated risk genes and understanding their mechanisms remains challenging, particularly concerning their influence on brain circuitry formation. Research has spotlighted the 15q13.3 microdeletion in humans as strongly linked to various psychiatric manifestations, with Klf13 gene emerging as a key player in neuronal pre