ePoster · Neuroscience
Group I metabotropic glutamate receptor-mediated modulation of mono- and disynaptic transmission in the human neocortex
Joanna Sandle, Gábor Molnár, Katalin Kocsis, Martin Tóth, Emőke Bakos, Pál Barzó, Karri Lamsa, Gábor Tamás · FENS Forum 2024
Activation of group I metabotropic glutamate receptors (mGluR) in the brain mediates changes in neuronal excitability, synaptic transmission, and network activity of cortical circuits and has been linked to learning-related plasticity, brain state-modulation as well as various human neurological disorders but studies investigating their effect in human brain are scarce and mostly focused on excitatory neurons. We studied the effects of group I mGluR activation on monosynaptic glutamatergic synapses arriving onto interneurons and disynaptic GABAergic synapses using dual whole-cell patch clamp r