Altered firing and dopamine release in Substantia Nigra dopaminergic neurons induced by exposure to alpha-synuclein oligomers: From patch-clamp to diamond multielectrode arrays
Valentina Carabelli, Giulia Tomagra, Federico Picollo, Andrea Marcantoni · FENS Forum 2024
Parkinson's disease is a motor and cognitive neurodegenerative disorder associated to the progressive loss of Substantia Nigra pars compacta dopaminergic neurons. One cause of the disease is associated with the spreading of α-synuclein aggregates. Recent findings indicate that extracellular α-synuclein oligomers represent the most neurotoxic species and reduce the firing discharge of midbrain neurons, impair network synchronization, up-regulate Cav2.2 Ca channels and neurotransmitter release in cortical neurons. Here we combined conventional electrophysiology (current-clamp) and diamond multi
ePoster · Neuroscience