Cellular and synaptic alterations of arkypallidal neurons in experimental parkinsonism and L-DOPA-induced dyskinesia
Bonamy Léa, Zhara Ghasemi, Jérôme Baufreton · FENS Forum 2024
The external Globus Pallidus (GPe) is a central hub in the basal ganglia. This structure is composed mainly of GABAergic neurons, which are divided into two distinct subtypes called: prototypic (70%) and arkypallidal (ARKY: 20%) neurons differentiated by their molecular and electrophysiological signatures. ARKY neurons project exclusively to the striatum and send a stop signal that interrupt ongoing action, suggesting their key role in movement control. However, little is known about the contribution of ARKY neurons to the pathophysiology of Parkinson’s Disease (PD). Moreover, it has been rece
ePoster · Neuroscience