Topic: DISC1 aggregates-positive microglia

Microglia, as macrophages in the brain, exhibit dysfunction with aging, such as impaired phagocytic capability and elevated neuroinflammation. However, the mechanisms underlying microglial aging remain unclear. The heterogeneity of microglia further challenges this context. Disrupted-in-schizophrenia 1 (DISC1), a psychiatric disorder susceptibility gene disrupted by translocation, plays an essential role in regulating the development and function of neurons. We observe that DISC1 is also expressed in microglia, where it exhibits an aggregates-like pattern (Figure A). We called this population