GABAergic neurons in the rostromedial tegmental nucleus mediate transitions from REM sleep to arousal in mice
Surong Yang, Ya-Nan Zhao, Jian-Bo Jiang, Yang Zhang, Liu-Yan Chang, Wei-Min Qu, Zhi-Li Huang · FENS Forum 2024
Aims: Compared with non-rapid eye movement (NREM) sleep, rapid eye movement (REM) sleep is characterized by low-voltage and fast electroencephalographic activity, loss of muscle tone, or intermittent muscle twitches. Waking up from REM sleep is necessary for staying alert in animals, yet it is not well known about the mechanism of the transitional signature of REM sleep. Methods: Neuronal activities of the rostromedial tegmental nucleus (RMTg), a structure in the midbrain that is primarily composed of GABAergic neurons, were manipulated using optogenetics. Electroencephalogram and electromyog
ePoster · Neuroscience