An ex-vivo brain slice model to assess the impact of elevated extracellular glutamate and EAAT blockade on synaptic and extrasynaptic NMDA receptor function
Maite Börsig, Patricia Scharf, Christoph Trebesius, C. Peter Bengtson · FENS Forum 2024
The overload of glutamate transporters by excessive extracellular glutamate leads to excitotoxic cell death in multiple neurodegenerative diseases as well as stroke, hypoxia and traumatic brain injury. The sustained activation of extrasynaptic N-methyl-D-aspartate (NMDA) receptors by excess extracellular glutamate has been implicated in multiple disease models in vitro and in vivo. Pathological levels of extracellular glutamate arise from compromised or even reversed function of excitatory amino acid transports (EAATs) in a brain region and subtype dependent manner. We have used whole cell pat
ePoster · Neuroscience