NR5A2 coordinately regulates hypoxia response and metabolism in neural cells: Implications for nervous system-related diseases
Dimitrios Gkikas, Milioti Panagiota, Markidi Eliana, Nomikou Angeliki, Stergiopoulos Athanasios, Rozani Ismini, Kaltezioti Valeria, Vatselas Giannis, Valakos Dimitrios, Politis Panagiotis K. · FENS Forum 2024
Metabolic regulation in the nervous system plays a pivotal role in orchestrating neuronal function and maintaining cellular homeostasis. Utilizing our RNAseq data from gain- and loss-of-function studies of embryonic neural tissue and neuronal cells, we demonstrate that the nuclear receptor NR5A2 regulates hypoxia response, glycolysis, and fatty acid metabolism. Consistently, we have previously shown that NR5A2 inhibits the proliferation and growth of glioblastoma cells and tumors, respectively. Here, we elucidate a novel mechanism whereby NR5A2 functions as a potent suppressor of HIF-1α (Hypox
ePoster · Neuroscience