Molecular changes underlying decay of sensory responses and enhanced seizure propensity in peritumoral neurons
Elisa De Santis, Elena Tantillo, Marta Scalera, Nicolò Meneghetti, Chiara Cerri, Michele Menicagli, Alberto Mazzoni, Mario Costa, Chiara Maria Mazzanti, Eleonora Vannini, Matteo Caleo · FENS Forum 2024
In recent years, the interaction between glioma and brain cells has emerged as one important regulator of tumor progression. In order to investigate the molecular and physiologic alterations of the peritumoral neurons induced by glioma growth, we used two well-established glioma syngeneic cell lines: GL261 and CT-2A. We performed in vivo electrophysiological recordings of visual evoked potentials (VEPs) to longitudinally monitor the neural dysfunctions along with tumor progression. With respect to controls, glioma-bearing (GBM) mice showed a decay of visual responses that started from day 14 a
ePoster · Neuroscience