Topic: dmPFC neurons

Social status affects health by influencing the capacity of the immune system to respond to infection and disease. However, the neuronal mechanisms that explain how social status causes individual differences in immunity are unknown. In this study, we observed that among social groups of four male mice, those ranked second in hierarchy display superior T-cell expansion upon vaccination. The improved T-cell responses in second ranked mice were dependent on the ability of synaptic communication in the brain. The brain circuits that control the position in the social hierarchy are beginning to em