Topic: DNA glycosylase

The hippocampus' role in spatial cognition is well-established, with place cells encoding environmental spatial information and interneurons modulating neural circuitry. Our research explores the role of NEIL3, a DNA glycosylase, in hippocampal neural processing. To determine the role of NEIL3 in the functioning of hippocampal neurons, we conducted in-vivo electrophysiological recordings to measure the activity of place cells and inhibitory interneurons in the hippocampus of both wild-type mice and mice lacking NEIL3 (Neil3-/-). We found that NEIL3-deficient CA1 place cells maintain normal spa