ePoster · Neuroscience
The interplay between oxidative stress, mitochondrial dysfunction, and alteration of parvalbumin interneurons in postmortem brain of Alzheimer’s disease and mild cognitive impairment patients
Andrea Piotti, Emylène Ostertag, Zeinab Ek Hajj, Ines Khadimallah · FENS Forum 2024
Alzheimer's disease (AD) is the most prevalent form of dementia, characterized by a progressive decline in cognitive function that ultimately leads to mortality. Timely detection, particularly during the early-stage of mild-cognitive-impairment (MCI) is crucial for effective intervention. Converging evidence showed that parvalbumin-interneurons (PVI) cortical microcircuitry play an important role for normal cognitive functions. PVI are highly sensitive to oxidative stress (OS) and mitochondrial impairment, conditions that are well known to increase with ageing. Therefore, there is a critical n