Modulation of direct pathway regulates motor symmetry in the unilateral 6-OHDA rat model of PD
Rafaël De Sa, Arend Vogt, Elisa Garulli, Burce Kabaoglu, Matej Skrobot, Vitali Merhi, Benjamin Rost, Dietmar Schmitz, Nikolaus Wenger · FENS Forum 2024
Parkinson's disease (PD) is characterized by progressive dopaminergic depletion in the striatum leading to motor deficits that often manifest with asymmetry. In this study, we investigated the role of optogenetic activation of the direct pathway in its ability to reestablish motor function and regulate oscillatory activity in cortex-basal ganglia loops. Rats received a unilateral injection of 6-OHDA into the medial forebrain bundle, followed by the delivery of adeno-associated viruses (AAVs) that specifically transduced Dopamine-1-Receptor-positive medium spiny neurons (DRD1-neurons). Using th
ePoster · Neuroscience