Topic: dopamine cells

Conventional approaches to behavioral correction, aimed at curbing addictive behaviors, often involve methods like electric shocks, which, while effective, pose a risk of harm due to induced nociceptive pain. Recent findings show that calcitonin gene-related peptide in the parabrachial nucleus (CGRPPBN) provides affective pain signals and generates general alarm signals. Here we investigated whether stimulating CGRPPBN neurons could replicate the behavioral correction effects of electrical shock, thereby suppressing addictive behavior without causing physical harm. Using Calca-Cre::DAT-Cre mic