New generation of genetically encoded dopamine sensors for imaging brain-wide dopamine release
Julie Chouinard, Rochelin Dalangin, Kenta M. Hagihara, Bryan J. MacLennan, Katharine Borges, Patrick R. Melugin, Carina Soares-Cunha, Shouvik Majumber, Erin C. Scott, Nikki Tjahjono, Kiyoto Kurima, Sakiko Takahashi, Dvyne Nosaka, Peter T. Freitas, Karan Mahe, Viviana Gradinaru, Hidehiko Inagaki, Kaspar Pogdorski, Na Ji, Cody A. Siciliano, Jeffery R. Wickens, Lin Tian · FENS Forum 2024
Recent advances in biosensor technology have paved the way for an unprecedented level of inquiry into the spatiotemporal dynamics of neurochemical release in the brain. These sensors directly and specifically report synaptic signals as they are received by their receptors. dLight is a family of dopamine sensors with broadly tuned apparent affinity and dynamic range suitable to measure dopamine release between pM and µM range. They exhibit high affinity, millisecond response times, high signal-to-noise ratio (SNR), along with expression and targeting suitable for use in vitro and in vivo to tra
ePoster · Neuroscience