Exploring the neuroprotective effects of nicotine against MPTP-induced neuronal damage in mice: Insights into antioxidant system
Nikoloz Zhgenti, Otar Bibilashvili, George Burjanadze, Mariam Shengelia, Elene Davitashvili, Nana Koshoridze · FENS Forum 2024
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder, following Alzheimer's disease. It is characterized by the degeneration of dopaminergic neurons in the SNpc, resulting in both motor and non-motor symptoms. Current treatments are limited, and PD's molecular basis involves alpha-synuclein aggregation, ubiquitination dysregulation, and oxidative stress. Nicotine, found in tobacco, has been associated with reduced PD risk in epidemiological studies and shown neuroprotective effects in animal models. However, its impact on oxidative stress remains unclear. A study in
ePoster · Neuroscience