The role of COMT Val158Met polymorphism impacts the performance in solving transitive inference problems
Ann Paul, Isabel Beatrice Marc, Maria Teresa Fiorenza, Sonia Canterini, Stefano Ferraina, Pierpaolo Pani, Emiliano Brunamonti · FENS Forum 2024
The Catechol-O-Methyl-Transferase (COMT) gene plays a crucial role in dopamine (Da) metabolism within the prefrontal cortex, exerting a direct impact on essential cognitive processes. This study aims to explore the influence of how the Val158Met polymorphism in the COMT gene impacts the solution of inferential problems through a transitive inference task. 83 participants were categorized into three COMT genotypes: Met/Met, Val/Val, and Val/Met. Initially, they were instructed to learn the relationships between adjacent pairs of items in a rank-ordered set (A>B>C>D>E>F) through t
ePoster · Neuroscience