Prefrontal-tDCS rescues hippocampal dopamine signalling, resulting in cellular, functional and behavioural improvements and amyloid-β reduction in a mouse model of Alzheimer’s disease
Maria Luisa De Paolis, Livia La Barbera, Gilda Loffredo, Annalisa Nobili, Paraskevi Krashia, Marcello D’Amelio, Emanuele Claudio Latagliata · FENS Forum 2024
We have previously shown a precocious and selective dopamine neurodegeneration in the Ventral Tegmental Area (VTA) of Tg2576 mice, a reliable experimental model of Alzheimer’s Disease (AD). In this model, the VTA neuronal loss causes the decrease of dopamine outflow in the Hippocampus and the Nucleus Accumbens, leading to impaired synaptic plasticity, memory and reward processing. Mesocorticolimbic system deficits are also reported in AD patients. Interestingly, pharmacological interventions aimed at improving DA levels ameliorate AD deficits in mice.However, drug-based treatments might cause
ePoster · Neuroscience