Alpha-synuclein induced immune response triggers Parkinson’s disease
Rebekah G Parkinson, Tony Xu, Zizheng Xian, Jacob Martin, Jessica A Pettitt, Ilvana Ziko, Alexandre RCom-H'Cheo-Forgues, Rebecca Buckland, Sarah Gordon, Christopher Parish, Anne Brustle, Nathalie Dehorter · FENS Forum 2024
Parkinson's disease has been characterized by the significant role that alpha-synuclein and immune activation play in driving disease progression. Moreover, the immunogenicity of alpha-synuclein-derived epitopes in driving both innate and adaptive immunity has been discovered in prodromal Parkinson's disease. Despite these findings, the mechanistic role of the immune system in contributing to disease ontogenesis remains unknown. Recent evidence has identified alpha-synuclein as a candidate biomarker, with seed amplification assays yielding high sensitivity for sporadic cases of the disease. Pe
ePoster · Neuroscience