Achyrocline satureioides protects against neuronal dopaminergic damage in the Caenorhabditis elegans model of Parkinson’s disease
Patrícia Pereira, Peterson Alves Santos, Pricila Pflüger, Ionara Rodrigues Siqueira, Jose Angel Fontenla · FENS Forum 2024
Achyrocline satureoides aqueous extract (ASAE) protective effects were evaluated on dopaminergic neurodegeneration induced by reserpine in Caenorhabditis elegans (C. elegans). Strain BY200 was cultured following standard procedure. The worms (L1 stage) were exposed to the treatments, ASAE (10 or 25 mg/ml) or no for 24 hours, followed by the induction of dopaminergic damage (reserpine, 60 µM, positive control; PC) or no (negative control; NC). Worm’s images (n=20) were captured using a fluorescence microscope and quantified using the ImageJ software. The locomotor behavior (body bends) of the w
ePoster · Neuroscience