hiPSC-derived dopaminergic and glutamatergic neurons of schizophrenia patients show neuronal aberrations in a co-culture model
Sophia-Marie Hartmann, Johanna Heider, Sabrina Vogel, Ricarda Breitmeyer, Richard Wüst, Andreas J. Fallgatter, Hansjürgen Volkmer · FENS Forum 2024
Schizophrenia (SCZ) is characterized by the aberrant development of the central nervous system and thereby results in impairments of multiple aspects of synaptic transmission, neuronal connectivity, and activity patterns. Dysfunctions of the dopaminergic circuitry were already postulated several decades ago. Patients with SCZ suffer from disturbances in the reward system, as well as in executive and cognitive functions. The two dopaminergic pathways, mesolimbic and mesocortical, have been implicated in neuropsychiatric disorders. Both originate from the ventral tegmental area and project to th
ePoster · Neuroscience