Differential metabolism of serine enantiomers in the striatum of MPTP-lesioned monkeys and mice correlates with the severity of dopaminergic midbrain degeneration
Marcello Serra, Anna Di Maio, Valentina Bassareo, Tommaso Nuzzo, Francesco Errico, Federica Servillo, Mario Capasso, Pathik Parekh, Qin Li, Marie-Laure Thiolat, Erwan Bezard, Paolo Calabresi, David Sulzer, Manolo Carta, Micaela Morelli, Alessandro Usiello · FENS Forum 2024
In the mammalian brain, D-/L-serine regulates fundamental physiological processes including synaptic plasticity, energy homeostasis, lipid metabolism, and cell survival. Recent findings from our group (Di Maio et al., 2023) indicated notable variations in serine enantiomer concentrations in the caudate-putamen of Parkinson's disease (PD) patients and the CSF of de-novo PD patients. Nevertheless, the impact of the severity of dopaminergic loss on the central levels of serine enantiomers remains uncertain. To gain deeper insight into this matter, the current study examines the occurrence of cent
ePoster · Neuroscience