Functional, behavioural and molecular characterization of a presymptomatic model of Parkinson disease expressing α-synuclein in the locus coeruleus
Jone Razquin, Laura De Las Heras-García, Celtia Domínguez-Fernández, Lorena Delgado, Jérôme Baufreton, Jose Angel Ruiz-Ortega, Gloria González-Aseguinolaza, Edgar Soria-Gomez, Naiara Ortuzar, Harkaitz Bengoetxea, Cristina Miguélez · FENS Forum 2024
Parkinson’s disease (PD) is a neurodegenerative process characterized by the presence of Lewy bodies in different brain regions, affection of many neurotransmitter systems and manifestation of motor and nonmotor symptoms. These latter ones often appear before the motor symptomatology and highly impact on the life quality of the patients. Interestingly, the locus coeruleus (LC) that contains the highest density of noradrenergic neurons in the brain, is among the brain stem areas first displaying Lewy bodies in the disease, and is associated with prodromal non-motor symptoms. Despite its small s
ePoster · Neuroscience