Understanding midbrain dopaminergic cell fate acquisition using midbrain-like organoids for Parkinson’s disease cell therapy
Hilary Toh, Audrey Khoo, Adeline H. Basil, Lisheng Xu, John F. Ouyang, Alfred Sun · FENS Forum 2024
Midbrain dopaminergic (mDA) neurons in the substantia nigra are selectively degenerated in Parkinson’s disease (PD), leading to motor deficits and a broad range of non-motor symptoms. As no curative treatment currently exists for PD, cell replacement therapy involving the transplantation of dopaminergic neuron precursors into patient brains represents a promising mode of treatment. Several studies have shown a range of transcriptional subtypes that exist among mDA neurons, with implications for their eventual axonal targets and synaptic function. Grafts that contain contaminating cell types su
ePoster · Neuroscience