Understanding the role of striatal cholinergic interneurons in reward and motivation processing
Suellen Almeida-Correa, Bastiaan van der Veen, Lucas Yebra, Matthias Heil, Hsing-Jung Chen-Engerer, Johann du Hoffmann, Marzieh Funk, Wiebke Nissen, Roberto Arban · FENS Forum 2024
The dopaminergic striatal circuit is a key hub for processing reward and motivation in the brain. The main cell types of this circuit are the medial spiny neurons (MSNs), which are dynamically controlled by the interneurons of the region. Among these, the cholinergic interneurons (CINs) represent only 1-3% of the total neurons of the striatum but potentially exert a fundamental role in controlling the activity of the MSNs and local dopamine release. The overarching objective of this study is to assess the role of CINs in modulating striatal dynamics. Considering their striatal localization and
ePoster · Neuroscience