Investigating the synaptic dynamics of adaptive behavior in the mouse frontal cortex
Ioanna Pandi, Hatem Oraby, Mostafa Nashaat, Matthew Larkum, Athanasia Papoutsi, Panayiota Poirazi · FENS Forum 2024
In this world of unexpected change, animals face a critical trade-off between retaining older information and facilitating new learning. Dendritic spines, where excitatory synapses are located, represent the basic structural and functional unit of learning and memory at the neuronal level; spines are formed and/or modified during learning to support behavioral demands. However, how the interplay between plasticity and stability in dendritic spines is implemented to accommodate adaptations in behavior remains unclear. We investigated this question in head-fixed mice performing a rule-switch beh
ePoster · Neuroscience