Systemic low-doses ketamine disrupts non-navigational spatial memory in non-human primates
Carolina Campos Rodriguez, Carleigh Turner, Anjik Ghosh, Patrick Forcelli, Ludise Malkova · FENS Forum 2024
Ketamine is a non-competitive NMDA antagonist with hallucinogenic, analgesic and anesthetic properties. It has been repurposed for the treatment of depression, but its narcotic properties have made it attractive for recreational abuse. Consistent with the findings that non-competitive NMDA antagonists disrupt memory, studies in humans and monkeys have demonstrated impartment in cognitive functions, including memory, even with low doses of ketamine. Previously, our laboratory has shown, in macaques, that transient inactivation of the hippocampus by intracerebral infusion of the GABAA agonist mu
ePoster · Neuroscience