Gene expression alterations in the hippocampus of a murine model of Prader-Willi syndrome
Esteban Jiménez-Villalba, Laura Lázaro-Carot, Ana Perez-Villalba, Sacri R. Ferrón · FENS Forum 2024
Prader-Willi Syndrome (PWS) is a neurodevelopmental disorder caused by the loss of the expression of the paternally expressed genes contained at PWS locus, located at chromosome 15 in humans. The most common molecular cause of the syndrome is a deletion of some of the genes located in this cluster, and specifically, a critical region (PWScr) has been postulated as the minimal deletion capable of giving rise to a PWS phenotype. This region contains several tandem-repeated copies of snoRNA-coding gene SNORD116 and the non-coding gene IPW. In adult mammals, new neurons are produced along the whol
ePoster · Neuroscience