Adult hippocampal neurogenesis, the post-mortem delay, and prolonged aldehyde fixation: The enemies within
Marta Gallardo Caballero, Carla Rodríguez Moreno, Laura Álvarez Méndez, Júlia Terreros Roncal, Miguel Flor García, Elena Moreno Jiménez, Alberto Rábano, María Llorens Martín · FENS Forum 2024
Adult hippocampal neurogenesis (AHN) gives rise to new neurons throughout life. This phenomenon takes place in more than 120 mammalian species, including humans, yet its occurrence in the latter was questioned after a putative absence of neurogenesis markers in the adult human hippocampus was suggested. In this regard, we showed that prolonged fixation impedes the visualization of Doublecortin+ immature neurons in this structure, whereas a dilated post-mortem delay (PMD) has been suggested to underlie these discrepancies. Nevertheless, the individual and/or additive contribution of fixation an
ePoster · Neuroscience