DREAM protein inhibition as a potential treatment against NAFLD and metabolic syndrome and its associated neurologic signs in mice
José Manuel Hernández Curiel, Ángel Manuel Carrión Rodríguez, Juan Antonio Fernández Cabrera, Inés Sánchez Romero · FENS Forum 2024
High fat diet (HFD) chronic intake induces metabolic syndrome in mice, characterized by a body weight increase and insulin resistance (IR). Furthermore, non-alcoholic fatty liver disease (NAFLD) is strongly linked to metabolic syndrome appearance. Obesity is a risk factor in the development of neurodegenerative diseases, neuropsychiatric disorders and is associated with cognitive decline. DREAM/kchip3/calsenilin (DREAM) is a multifunctional protein that belongs to the neuronal Ca2+ sensor family. Previous studies have demonstrated the relevance of DREAM in nociception and in learning and memor
ePoster · Neuroscience